You can bake this John Wayne Casserole when you want a bold, beefy, cheesy Southwestern-style dinner that feels like pure comfort food in one pan. Seasoned taco beef, peppers, and tomatoes sit on a soft biscuit crust under a tangy sour cream–cream cheese layer and plenty of melted cheddar.
Why You’ll Love This John Wayne Casserole
You’ll love how this casserole layers flavors and textures: buttery biscuit base, saucy taco-seasoned beef with peppers and tomatoes, and a cool, creamy topping that bakes into a cheesy, golden blanket. It uses familiar pantry staples—ground beef, taco seasoning, biscuit mix, sour cream, and cheddar—so it’s easy to throw together on a busy weeknight. The recipe also scales well and holds up for leftovers, which is why versions of John Wayne casserole have become staples on family dinner and potluck lists.